https://www.selleckchem.com/pr....oducts/ziftomenib.ht
01). SSd significantly decreased the MDA and MSP levels and increased the activities of SOD, GPx, and CAT (all P less then 0.05). The mRNA expression of NLRP3, ASC, and Caspase 1, and the protein expression of Caspase 1-p10, NLRP3, ASC, IL-1β, and IL-18 were significantly increased after CCl4 induction (all P less then 0.01). These changes were reversed by SSd (all P less then 0.05).Suppression of the oxidative stress and NLRP3 inflammasome activation were involved in SSd-alleviated acute liver injury in CCl4-induced hepatitis.
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