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The objectives were to investigate the relationship between ketogenic diet therapy and neutropenia in children with epilepsy. A retrospective chart review of children who initiated ketogenic diet at the Hospital for Sick Children between January 1, 2000, and May 1, 2018 was performed. Factors associated with the development of neutropenia during ketogenic diet therapy were evaluated and the relationship between development of a significant or suspected infection and neutrophil count was analyzed. One hundred two children met inclusion c

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