https://www.selleckchem.com/pr....oducts/agi-24512.htm
Viruses are remarkable self-assembled nanobiomaterial-based machines, exposed to a wide range of pH values. Extreme pH values can induce dramatic structural changes, critical for the function of the virus nanoparticles, including assembly and genome uncoating. Tuning cargo-capsid interactions is essential for designing virus-based delivery systems. Here we show how pH controls the structure and activity of wild-type simian virus 40 (wtSV4 and the interplay between its cargo and capsid. Using cryo-TEM and solution X-ray scattering, w
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