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Contact-based interventions are commonly regarded as best practice in stigma reduction. In this Open Forum, the author used the findings from eight systematic reviews to critically evaluate the quality of the evidence for the effectiveness of such interventions. He found that trials of contact-based interventions lacked methodological rigor, reporting was biased toward positive results, the trials were subject to demand characteristics, no dose effects were observed, effects did not last, and no evidence supported behavior change. Stand

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We find that the thermodynamic efficiency of this machine is zero because the field for the isothermal processes acts as a refrigerator, whereas that for the adiabatic wall acts as a heat engine. This is a numerical manifestation of the Kelvin-Planck statement, which states that it is impossible to derive the mechanical effects from a single heat source. These HEOM simulations serve as a rigorous test of thermodynamic formulations because the second law of thermodynamics is only valid when the work involved in the operation o