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Remdesivir is one of the most promising drugs to treat COVID-19 based on the following facts remdesivir has a broad-spectrum antiviral mechanism of action; it demonstrated in vitro activity against SARS-CoV-2 and in vivo efficacy in animal models against the similar coronavirus MERS-CoV; its safety profile has been tested in Ebola patients and in compassionate use in COVID-19 patients. Currently, remdesivir is being investigated in ten randomized controlled trials against COVID-19. The dose regimen of remdesivir is an IV loa

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The purpose of this study was to assess the effect of downsampling the acoustic signal on the accuracy of linear-predictive (LPC) formant estimation. Based on speech produced by men, women, and children, the first four formant frequencies were estimated at sampling rates of 48, 16, and 10 kHz using different anti-alias filtering. With proper selection of number of LPC coefficients, anti-alias filter and between-frame averaging, results suggest that accuracy is not improved by rates substantially below 48 kHz. Any downsampling should not