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A total of eight therapy recommendations were provided. Based on our observations, molecular-guided therapies may be a feasible treatment approach for this rare disease entity. The aim of the study was to assess (1)sports activity, (2)sports involving the upper extremities, (3)functional outcome and (4)sports-related complications of long-term survivors of primary malignant bone tumors of the proximal humerus. A total of 18 patients with an endoprosthetic reconstruction for primary malignant bone sarcoma of the proximal