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Our findings indicate that MITF gene rearrangements may be key drivers of tumor pathogenesis and expand the spectrum of neoplasia associated with the MIT/TFE family.Since the advent of Paul Grammont medialized reverse shoulder prosthesis in the 1980s, shoulder surgeons have had a reliable option for treating glenohumeral joint disease in the rotator cuff-deficient shoulder. However, the prosthesis is not without complications, including scapular notching, instability, and limited rotational motion. Implants have been modified from the