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is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to infection has not been studied on a large-scale. A total of 1,160 infection cases and 15,304 controls were identified by applying the eMERGE infection algorithm to electronic health record data. A genome-wide association study was performed using a linear mixed model, adjusted for significant covariates in the full dataset and the antibiotic subgroup. Colocalization and MetaXcan were performed to identify potential target genes in i