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Thus, post-translational modification can alter the structure and regulate the function of hHsp70. Published under license by The American Society for Biochemistry and Molecular Biology, Inc.Interleukin 11 (IL-11) activates multiple intracellular signalling pathways by forming a complex with its cell surface α-receptor, IL-11Rα, and the β-subunit receptor, gp130. Dysregulated IL-11 signalling has been implicated in several diseases, including some cancers and fibrosis. Mutations in IL-11Rα that reduce signalling are also associated with