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How a VC Can Affect Your Heart Many people experience occasional PVCs with no problems. If they occur often, PVCs may weaken your heart and increase the risk for heart failure. The heart's rhythm is usually controlled by a bundle of nerve fibers situated in the upper right-hand corner of your heart. This is known as the sinoatrial node, or SA. Electrical signals travel from there to the lower chambers of your heart, or ventricles. Causes PVCs happen when the electrical impulse that normally triggers your heartbeat at th