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46.7 ± 8.8 ng/mL). Serum progranulin was also evaluated as an independent predictive factor for postoperative 1-year RA disease activity in multivariate analysis (odds ratio [OR], 2.21; 95% confidence interval [CI], 1.02-8.85). Serum progranulin levels may be a promising indicator of postoperative disease activity in RA patients who underwent orthopedic surgery. Serum progranulin levels may be a promising indicator of postoperative disease activity in RA patients who underwent orthopedic surgery.Introduction Cholangiocarcinomas (CCAs) ar