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The methodology is best in a position to pinpoint the placement of the ligand binding site than a comparable pocket detection algorithm (Pocket-Finder) on a dataset of 134 proteins. One of the strengths of the strategy is its prediction of relatively small sites. The sites have volumes roughly equivalent to ligand volumes no matter the overall size of the protein. This is in contrast to pocket detection, where predicted website volumes show a a lot higher tendency to extend with protein size. This property would appear to be a results of utilizing probe web sit

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