https://www.selleckchem.com/pr....oducts/brivudine.htm
The increased ATP/O ratio observed in cells from old compared to adult rats was diminished after stimulation of cGMP-signaling. Opposite, long-term-PDE5-inhibition decreased cGMP-signaling and improved mitochondrial function/dynamics in Leydig cells from old rats. Mitochondrial abundance in Leydig cells decreased while ATP levels increased. Chronic-treatment elevated Tfam, Nrf1, Nrf2, Opa1, Mfn1, Drp1 and normalized Pink1 expression. Altogether, long-term-PDE5-inhibition prevented age-related NO and cGMP elevation, improved mitochondr
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