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The objective of this study was to develop a robust prediction model for the infinite dilution activity coefficients (γ ∞) of organic molecules in diverse ionic liquid (IL) solvents. Electrostatic, hydrogen bond, polarizability, molecular structure, and temperature terms were used in model development. A feed-forward model based on artificial neural networks was developed with 34,754 experimental activity coefficients, a combination of 195 IL solvents (88 cations and 38 anions), and 147 organic solutes at a temperature range of 298 to 408 K. The root mean s