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5)-related premature deaths; The corresponding health economic loss was about 35.934 billion (95%CI 26.099 billion - 43.255 billion) RMB, accounting for 0.70% (95%CI 0.51%-0.85%) of the area's GDP in 2015, Beijing, Tianjin, Baoding, Shijiazhuang, and Cangzhou were the top five cities with high health economic loss. Conclusions PM(2.5) pollution has caused severe disease and economic burden in BTH area. Its spatial distribution suggested that it is particularly necessary to develop the air pollution prevention and control policies for k