https://dub-signaling.com/inde....x.php/ethnic-backgro
Transgenic PTEN mice designs tend to be resistant to oncogenic change, present decreased adiposity and reduced cellular sugar and glutamine uptake, together with increased mitochondrial oxidative phosphorylation. These purchases generated a novel understanding in connection with role of PTEN to counteract cancer cell metabolic reprogramming. Particularly, PTEN drives an "anti-Warburg state" for which less glucose is adopted, however it is better directed towards the mitochondrial Krebs cy
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