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Several experiments are carried out to evaluate the performance of the proposed hybrid method. The metrics of full width at half maximum (FWHM), contrast recovery (CR), and coefficient of variation (COV) are adopted to quantitate the imaging results. The classical MC-based method is compared as a gold-standard reference. When a crystal is divided into two discretized positions, the convergent tendencies of CRs and COVs are consistent with that based on MC simulation method, respectively. In terms of FWHMs, the resolutions of using the MC