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Providing unawareness and pain relief are core elements of palliative sedation. In addition to clinical scales, nociception and electroencephalogram-based depth of sedation monitoring are used to assess the level of consciousness and analgesia during sedation in intensive care units and during procedures. To determine whether reported devices impact the outcomes of palliative sedation. Systematic review and narrative synthesis of research published between January 2000 and December 2020. Embase, Google Scholar, PubMed, CENTRAL, and the