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ADHD Treatment For Adults Stimulants like methylphenidate and amphetamine increase the levels of certain brain chemicals. Nonstimulants like atomoxetine or antidepressants work slower than stimulants, but they may be just as helpful. Comorbid conditions often affect the effectiveness of ADHD medications. The most severe symptoms from any comorbidity should be treated first. Then, the physician must be able to determine if ADHD symptoms improve. Medication Adults with ADHD are typically treated by medication. There are many types of medication availa