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The procedures of prenatal and preimplantation diagnostics are discussed critically again and again in our community. In addition to the permanently controversial issues of embryo protection and abortion, considerations that discrimination on the basis of disability could occur with problematic consequences also for already born people with disabilities and their relatives now play a central role. There are generally two major reasons for the comparison of reference intervals (RIs) when externally determined RIs (from the literature or provided by a manufac