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Steady mixed chimeras revealed threshold towards heart grafts from donors with MHC paired to either bone tissue marrow donors or recipients. Isolated matching of MHC course II with bone tissue marrow donors likewise resulted in stable tolerance as opposed to matching of MHC class I. In summary, MHC class II disparity had been critically from the start of graft-versus number infection and was defined as hurdle for effective improvement chimerism after bone tissue marrow transplantation an
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