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Toxin-antitoxin (TA) systems, abundant in prokaryotes, are composed of a toxin gene and its cognate antitoxin. Several toxins are implied to affect the physiological state and stress tolerance of bacteria in a population. We previously identified a chromosomally encoded hok-sok type I TA system in Erwinia amylovora, the causative agent of fire blight disease on pome fruit trees. A high-level induction of the hok gene was lethal to E. amylovora cells through unknown mechanisms. The molecular targets or regulatory roles of Hok were unknown

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Tumor size of malignant soft tissue tumors was significantly larger than that of benign soft tissue tumors (47.6mm vs. 31.0mm, respectively, P.001). However, the difference between benign and malignant bone tumors was not statistically significant with the numbers available. ROC curve determined that the optimum diagnostic cutoff value for soft tissue tumor size was 40mm, with a high area under the ROC curve 0.816 (95% CI 0.711-0.921, sensitivity 91.7%, specificity 70.5%) CONCLUSIONS We highlighted that bone and soft tissue tumors o