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It appears to be a very effective alternative to combination products suitable for a wide range of users. In our review article we focused on the circulating HPV DNA and its potential role in the pathogenesis of cervical cancer and in the evaluation of patients´ prognosis with cervical cancer Design The article is a systematic review study analyzing available scientific articles focused on the circulating HPV DNA. Clinic of Obstetrics and Gynecology, Jesenius faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia.