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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression Untreated ADHD can lead to chronic underachievement and depression. This is particularly evident when they don't achieve their personal and professional goals. Diagnoses can be difficult to make when there are commonalities in symptoms between ADHD and depression. However, identifying the signs is the first step toward receiving treatment. 1. Feelings of inadequacy Many people who suffer from untreated ADHD or depression that co-occurs are plagued by feelings of inadequate