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Higher LST in CTC were independent of CTC enumerated, clinically more indicative of aggressive behavior than co-occurring TSG losses, and molecularly associated to gains in chromosomal regions including PTK2, Myc and NCOA2, increased androgen receptor (AR) expression, and BRCA2 loss. In 57 patients with matched cell-free tumor DNA (ctDNA) data, CTC were more frequently detectable and evaluable for CNA analysis (in 73.7% vs 42.1%, respectively). CONCLUSIONS Our findings suggest that genomic instability in CTC is a hallmark of ad

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© 2020 The Authors. Development and Change published by John Wiley Sons Ltd on behalf of International Institute of Social Studies.BACKGROUND The clinicopathological parameters associated with glucose transporter-1 (GLUT-1) expression in advanced gastric cancer are still controversial. This study aimed to determine the clinicopathological parameters and prognosis associated with GLUT-1 expression in advanced gastric cancer. MATERIAL AND METHODS The GLUT-1 expression level of 234 consecutive gastric cancer samples was detected by