https://www.selleckchem.com/pr....oducts/sbi-0206965.h
Combination of CP-31398 and defactinib, a FAK inhibitor, also achieved synergistic inhibitory effects and increased p53 with FAK dephosphorylation levels greater than the single treatment. These data indicated that a p53-activating CP-31398 achieved growth inhibitory effects in combination with a MDM2 or a FAK inhibitor and suggested a possible reciprocal pathway between p53 elevation and FAK inactivation.Radiation-induced risks for all solid cancer incidence and mortality were studied in the cohort of Russian Chernobyl emergency wo