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How Does ADHD Medication Work? When one neuron sends a message to another, it makes use of neurotransmitters, chemicals. They need to traverse a small gap, which is known as a synapse. Certain ADHD medications make the passing along of these messages more efficient. They may aid neurons in releasing more neurotransmitters or slow down the process of reuptake (called Reuptake inhibitors). Doctors start ADHD patients with a low dose and monitor their response. They alter the dosa