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tion (applying automated seizure detection devices), impact on development, cognition and behaviour; future research should alsoinvestigate age-specific efficacy of ASMs and target underlying aetiologies. RCTs of monotherapy and head-to-head comparison of add-on ASMs are currently lacking. However, we found high-certainty evidence for overall seizure reduction with add-on lamotrigine and rufinamide, with low-certainty evidence for AE leading to study discontinuation compared with add-on placebo or another add-on ASM. The evidence for othe
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