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pear to convey any clinical advantage in this study over conventional approaches for primary TKR. There is little difference in PROMs between the various surgical approaches in TKR with all resulting in good outcomes. However, the conventional midvastus approach (used in 3% of cases) was associated with a 20% reduced risk of revision surgery compared to the most commonly used knee approach (the conventional medial parapatellar used in 91.9% of cases). This data supports the use of the midvastus approach and thus surgeons should consider utilisi

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These findings demonstrate that NO inhibits Acon activity through S-nitrosylation at Cys-594. In summary, these findings describe mechanism by which NO regulates GA biosynthesis via S-nitrosylation of Acon under HS condition in G. lucidum.Background The aim of this study was to report the contemporary management of Hirschsprung disease (HD) in New Zealand. Methods We undertook a national multi-centre retrospective review of all newly diagnosed cases of HD during a 16-year period (2000-2015). Demographics, genetic and syndromic associat