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Male, but not female, APP/PS1 and App mice had significantly thinner molar enamel compared to their wild type counterparts. These data support the idea that oral microbiome changes exist during AD in addition to changes in salivary Aβ and oral health. These data support the idea that oral microbiome changes exist during AD in addition to changes in salivary Aβ and oral health. To investigate DACH1 protein expression in lung cancer tissue and matched paracancerous tissue and explore its effect on proliferation, invasion, and apoptosis in