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.A snapshot of noteworthy recent developments in the patent literature of relevance to pharmaceutical and medical research and development.Aim To find out whether treatment with immune checkpoint inhibitors (ICIs) results in volume increase of the spleen. Patient methods We studied 49 stage III and IV melanoma patients with an indication for ICIs. Computer tomographic-assisted volumetry of spleens was performed. Results After 3 months, median spleen volume was significantly increased when compared with the baseline volume. At 3 mo