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Here, we now have exploited ligand-accelerated metal catalysis to repurpose known fluorescent probes for various metals, an innovative new method in probe development. We used the cleavage of allylic and propargylic ethers as platforms which were previously created for palladium. After a single experiment that combinatorially examined 800 reactions with two factors (steel and ligand) for every ether, we discovered a platinum- or copper-selective techn