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The approach taken for improving the brain-to-brain loop of medical testing, as fundament for better diagnostic stewardship, is explained. To probe the reference biomarkers used to manage chest pain (CP) by Italian internists. Two hundred and fifty-seven doctors registered as members of the Federation of Associations of Hospital Doctors on Internal Medicine of the Campania Region (FADOI-Campania) were surveyed by means of Google Forms platform. Each participant was asked to report his/her sex, age, and location and hospital size (beds i