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These data indicated that the adhesion and target chemokine could improve antigen distribution performance, which supplies a very important technique for the development of IPNV recombination Lactobacillus casei oral vaccine later on. The purpose of this research is to assess antidiarrheal task of SKB_Gutbiotic against castor-oil and E.coli induced diarrhoea in Swiss albino mice and Sprague Dawley rats. In present research three doses of SKB_Gutbiotic were tested against castor-oil caused diarrhoea in