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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medication is the first choice for ADHD treatment, because they are the most researched and have a rapid-acting effect. But they're not right for everyone. These medications increase the signaling between nerves and areas in the brain to lessen symptoms of ADHD. They can also have negative side effects, such as an appetite loss and changes in heart rate or blood pressure. Stimulants Stimulants are among the most popular tr