https://www.selleckchem.com/pr....oducts/Gefitinib.htm
A QSAR model was implied to predict IC50 of the compounds and to analyse the electrostatic and hydrophobic contour maps. The resulting hits were found to be modest IL2 inhibitors with predicted inhibitory activity in the range of 5.17-4.40 nM. Further Dynamic simulation studies were carried out to determine the stability of the inhibitor-IL2 complex. Our findings underline the potential of the novel compounds as valuable pharmacological agents in diseases characterised by IL2 overexpression. Our findings underline the potential of the
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