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We obtained resting-state functional magnetized resonance imaging (R-fMRI) and diffusion tensor imaging (DTI) from 31 unmedicated MDD customers and 32 cognitively normal (CN) subjects and finished a set of neuropsychological tests. Rich-club company, network properties, and coupling between architectural and functional connectivity (SC-FC) were explored. Also, whether these indices may potentially deliver effective medical predictive price for MDD clients had been examined. The MDD