https://www.selleckchem.com/products/SGI-1776.html
Intriguingly, the microRNA (miRNA) analysis revealed an increased expression of miR-193-5p, miR-221, miR-212, and miR-183-5p in CKD, while an increased mRNA expression of anti-inflammatory cytokines and reduced level of pS6K with attenuated miRNA was found in rapamycin-treated rats compared to the CKD animals. Conclusion Activation of mTOR is the major responsive element with activation of miRNAs as an elementary role in the progression of kidney disease. Hence, targeting mTOR would be a possible strategy of treatment for CKD.Backgroun
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