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39% and the second threshold value 5.47%, the magnitude of the impacts of PM2.5 pollution on U5MR significantly decreased accordingly. When the percentage of population with access to improved sanitation facilities in a country was over 41.3%, the health damaging effects were reduced by more than half. This paper fills the current gap of PM2.5 research in least developed countries and provides key policy recommendations.The complexity of hepatocellular carcinoma (HCC) challenges the identification of disease-relevant signals. C3G, a gua