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This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.BACKGROUND AND PURPOSE Hispidulin is a flavonoid isolated from Clerodendrum inerme that was found to remit intractable motor tics. Previously, we have found that hispidulin attenuates hyperlocomotion and the disrupted prepulse inhibition (PPI) induced by methamphetamine and N-methyl-d-aspartate (NMDA) receptor blockers, two phenotypes of schizophrenia resembling positive symdromes. Hispidulin can inhibit catechol-O-met
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