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The serum LRG levels correlated significantly with the serum levels of LDH, C-reactive protein, ferritin, AaDO2, %DLco, and total ground-glass opacity score. The survival rate after 24 weeks in patients with an initial LRG level ≥ 17.6 μg/mL (survival rate 40%) was significantly lower than that in patients with an initial LRG level less then 17.6 μg/mL (100%) (P = 0.0009). Conclusion The serum LRG level may be a promising marker of disease activity, progression, and prognosis in patients with DM-IP.Background The aim of this study wa