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Change of this crystal form to amorphous form of celecoxib was revealed because of the solid-state characterization scientific studies. The AFM study unfold the forming of discrete asymmetric nano particles. All mucoadhesive gels discovered to have good mucoadhesion and rheological home with good in vitro permeation of medicine. A comparative study and analytical evaluation unveiled that solution containing Carbopol 934 was found is ideal mucoadhesive in situ gel of nano particles of celecoxib with enhanced permeation variables.Ther