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Pandemics disrupt traditional health care operations by overwhelming system resource capacity but also create opportunities for care innovation. To describe the development and rapid deployment of a virtual hospital program, Atrium Health hospital at home (AH-HaH), within a large health care system. Prospective case series. Atrium Health, a large integrated health care organization in the southeastern United States. 1477 patients diagnosed with coronavirus disease 2019 (COVID-19) from 23 March to 7 May 2020 who received care via AH-HaH.