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PSA and PSAdt were independent predictors of the presence of extra-pelvic disease in the post-radiation cohort, with AUC of 85%. Time from treatment to scan was significantly longer for prostatectomy-bed-only recurrences than for those with bone or visceral disease (6.2±6.4 vs. 2.4±1.3 years, p less then 0.001). Conclusion 18F-DCFPyL-PET/CT offers high detection rates in BCR PCa patients. PSA and PSAdt are able to predict scan positivity and disease location. Furthermore, the presence of bone/visceral lesions are associat