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TMS data were compared to those obtained in a control group of ten healthy subjects (HS) matched by age, sex and education level. Post-COVID-19 patients reported marked fatigue according to FRS score (8.1±1.7) and presented pathological scores at the FAB based on Italian normative data (12.2±0.7). TMS revealed marked reduction of SICI, and disruption of LICI as compared to HS. SAI was also slightly diminished. The present study documents for the first time reduced GABAergic inhibition in the M1 in patients who recovered from COV