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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medication is the first choice for ADHD medication, as they're the most studied and have a fast-acting effect. But they're not for everyone. These medications enhance the signaling between brain regions and nerves to reduce ADHD symptoms. They can also cause negative side effects, such as the loss of appetite or changes in heart rate or blood pressure. Stimulants Stimulants are the most common treatments for ADHD. They are renowned for increasing the amount of time spent in school, decreasing hyperactivity