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0 to -9.6 ‰/100 mm). The isotope amount effect at each sampling sites appeared using only the data in the warm months without extreme weather.Introduction Sweeteners are substances used to replace sugar. They can either be chemically produced (artificial sweeteners) or extracted from plants (natural sweeteners). In the last two decades, there is an increased popularity in their role as sugar substitutes in individuals to promote weight loss or maintain glycemic control. However, despite their favorable effects, there is concern regarding