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ated with the change in Q-LES-Q-SF score (Q-LES-Q ). Regression analysis revealed that SDS and Q-LES-Q could be used to predict SDS , =0.391, while SDS and full-time employment status could be used to predict SDS , =0.640. Q-LES-Q could be used to predict Q-LES-Q , =0.294, while Q-LES-Q and full-time employment status could be used to predict Q-LES-Q , =0.591. Long-term regular medication can improve social dysfunction in patients with MDD and symptom relief is the basis for improvement of social function level and quality of life, while