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It was found that the O/N ratio did not rigorously represent the cross-linking amount of skin level, because besides the hydrolysis associated with the recurring acyl chloride impeding the amido relationship formation, the breaking of present amido bonds while the grafting of free trimesoyl chloride particles on the nascent membranes may also increase the O/N proportion during post-treatments. Then three systems including hydrolysis, inflammation rearrangement an

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