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How Does ADHD Medication Work? Medications reduce ADHD symptoms by increasing the levels of chemicals dopamine and noradrenaline which transmit messages between brain cells. The most commonly prescribed stimulants include methylphenidate and the atomoxetine. Finding the right dosage and medication can require a lot trial and error. Honest, open communication with your doctor is crucial. Stimulants The stimulant drugs prescribed to treat ADHD boost levels of the hormones dopamine an